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LifeScale’s unique microfluidic sensor detects individual bacteria in each well, enabling microbe replication and culture growth to be measured with unmatched precision. But LifeScale goes further – by measuring the mass of each bacterium, it generates a detailed population profile of each culture that leads to a faster and more accurate result
The video shows a population of Low Mass healthy organisms.
The video shows High Mass filaments indicating stressed organisms.
By combining the population profile data with advanced AI, LifeScale can determine correct MICs even for delayed‐growth phenotypes. The key is the information contained in individual cell masses. Delayed‐growth strains may not replicate for several hours; however, during LifeScale’s short incubation time, microbes still respond to antibiotics by changing their morphology and mass—producing filamentous forms or spheroplasts. LifeScale’s population profiles clearly reveal these responses, whereas a growth‐based AST can miss them, since they occur prior to replication and visible biomass increase.